4 articles
MIT researchers report that targeted lipid nanoparticles reprogrammed up to 80 per cent of natural killer cells in mice, clearing tumours and autoreactive T cells without ex vivo cell manufacturing.
Six patients treated with Beam's BEAM-301 needed less cornstarch and fasted longer, but follow-up is short and the lower-dose effect waned.
Two October papers pull together every trial of CAR T-cells made inside the body: 41 patients, responses in all four myeloma cases, and a median progression-free survival of four months.
By delivering barcoded gene cassettes at high copy number, each cell assembles a random pathway. Growth selection then found CHO and Jurkat lines that make their own valine, and CHO cells that make isoleucine.
