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Contrasting activation and blockade of the GIP receptor in distinct brain regions both promote weight loss in mice, revealing new therapeutic avenues for obesity.
The FDA’s approval of ovexorexton marks the first drug targeting the orexin pathway in narcolepsy type 1, addressing the disorder’s full symptom spectrum rather than isolated features.
A 2025 study reveals that corticotropin-releasing hormone released by oligodendrocyte precursor cells slows their differentiation, suggesting a role in coordinating the stability and timing of oligodendrocyte generation rather than simply promoting myelin repair.
Your DNA does not change, but how it behaves can. Epigenomics is revealing how lifestyle, environment, and aging influence gene activity and disease risk.
If traditional gene sequencing is like reading the ingredients list of a recipe, Spatial Transcriptomics (ST) is like watching the chef assemble the dish in real-time. Discover how mapping gene expression directly onto intact tissue slices is radically changing how we view complex cellular ecosystems like the Tumor Microenvironment, and paving the way for the next era of personalized medicine.
While traditional CRISPR-Cas9 broke ground in gene therapy and achieved historic clinical milestones, the field is rapidly shifting. To safely edit genes directly inside the human body, scientists need tools that are more precise and less damaging. Discover how next-generation technologies like Base Editing and Prime Editing work, their unique advantages, and the delivery hurdles they must overcome to reach the clinic.